Hemoglobin Variants: Biochemical Properties and Clinical Correlates
نویسندگان
چکیده
منابع مشابه
Hemoglobin Yakina. I. Clinical and biochemical studies.
Three members of a family who have erythrocytosis and a new hemoglobin, designated hemoglobin Yakima, are described. The abnormal hemoglobin is characterized by the substitution of histidine for aspartic acid at residue 99 in the beta-chain. Of three possible structure-function relations which would account for the increased oxygen affinity of hemoglobin Yakima, only two seem likely. These are:...
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Recent observations (1, 2) in certain American Negroes, of a previously unrecognized abnormal hemoglobin, now designated as hemoglobin C,2 constitute a significant advance in knowledge of familial anemias. The introduction of filter paper electrophoresis (3, 4) for identification of abnormal hemoglobins (5, 6) has facilitated the study of specimens of hemoglobin from a large number of subjects....
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Medicine
سال: 2013
ISSN: 2157-1422
DOI: 10.1101/cshperspect.a011858